A surface rendering of the binding site and a novel biochemical transformation depiction using the co-crystal structure of ODCase with a ligand.
3D Structure of ODCase and its first covalent inhibitor, 6-iodo-UMP (discovered in our labs). A potent inhibitor of plasmodial ODCase.
Integrated thinking in drug discovery! Its all about useful solutions improving quality of life for the patients.
In old days, before the Cannabis Act, this is how medical cannabis was shipped by licensed producers to registered patients!
A mechanism to inhibit serine proteases - for the first time, we isolated alpha-fluoroglycine and characterized it!
We love this compound, a "suicide" inhibitor to ODCase, and opened so many doors for the elucidation of mechanism
Dr. Kotra among the Panelists on "Medical Cannabis Treatment: Separating Myth From Fact, Cannabis at Work: One Year Later"; Conference Board of Canada and Globe & Mail